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Herbicide resistance in transgenic plants with mammalian P450 monooxygenase genes
Author(s) -
Inui Hideyuki,
Ohkawa Hideo
Publication year - 2005
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1012
Subject(s) - transgene , glufosinate , biology , genetically modified crops , genetically modified rice , gene , cyp2b6 , cyp2c19 , herbicide resistance , genetically modified organism , cytochrome p450 , microbiology and biotechnology , botany , genetics , enzyme , biochemistry , glyphosate , cyp1a2 , genotype
Transgenic potato and rice plants were generated by the introduction of human P450 species, CYP1A1, CYP2B6, CYP2C9 and CYP2C19, which metabolized a number of herbicides, insecticides and industrial chemicals. The transgenic potato plant T1977 co‐expressing CYP1A1, CYP2B6 and CYP2C19 genes showed remarkable cross‐resistance to several herbicides with different structures and modes of action due to metabolism of these herbicides by the P450 species expressed. The transgenic rice plant 2C9‐57R 2 expressing CYP2C9 gene showed resistance to sulfonylureas, and the transgenic rice plant 2C19‐12R 1 expressing CYP2C19 gene showed cross‐resistance to certain herbicides with different structures and modes of action. These transgenic plants appear to be useful for herbicide resistance as well as phytoremediation of environmental contaminants. Copyright © 2005 Society of Chemical Industry