The impact of toxicity dose‐response relationships on quantitative risk analysis results | Zendy

Ferguson Jeffrey S. | Zendy; Hendershot Dennis C. | Zendy

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The impact of toxicity dose‐response relationships on quantitative risk analysis results

Author(s) -

Ferguson Jeffrey S.,

Hendershot Dennis C.

Publication year - 2000

Publication title -

process safety progress

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.378

H-Index - 40

eISSN - 1547-5913

pISSN - 1066-8527

DOI - 10.1002/prs.680190208

Subject(s) - quantitative analysis (chemistry) , toxicity , risk assessment , risk analysis (engineering) , quantitative assessment , medicine , computer science , chemistry , computer security , chromatography

The toxicity dose‐response relationship is a critical data requirement for a quantitative risk analysis of a chemical processing facility. This paper will review: The use of toxicity dose‐response relationships in a quantitative risk analysis The development of dose‐response relationships for use in a quantitative risk analysis from toxicity data Examples of variation in published dose‐response relationships for some common chemicals The impact of differences in dose‐response relationships on the results of a quantitative risk analysisFinally, we propose the development of a standard protocol for development of toxicity dose‐response relationships for use in quantitative risk analysis, with emphasis on the benefits to the chemical industry of a standardized methodology.

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