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The impact of toxicity dose‐response relationships on quantitative risk analysis results
Author(s) -
Ferguson Jeffrey S.,
Hendershot Dennis C.
Publication year - 2000
Publication title -
process safety progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.378
H-Index - 40
eISSN - 1547-5913
pISSN - 1066-8527
DOI - 10.1002/prs.680190208
Subject(s) - quantitative analysis (chemistry) , toxicity , risk assessment , risk analysis (engineering) , quantitative assessment , medicine , computer science , chemistry , computer security , chromatography
The toxicity dose‐response relationship is a critical data requirement for a quantitative risk analysis of a chemical processing facility. This paper will review: The use of toxicity dose‐response relationships in a quantitative risk analysis The development of dose‐response relationships for use in a quantitative risk analysis from toxicity data Examples of variation in published dose‐response relationships for some common chemicals The impact of differences in dose‐response relationships on the results of a quantitative risk analysisFinally, we propose the development of a standard protocol for development of toxicity dose‐response relationships for use in quantitative risk analysis, with emphasis on the benefits to the chemical industry of a standardized methodology.