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Thermal hazard investigation of a pharmaceutical intermediate
Author(s) -
Zhao Ralph,
Muzzio Dan,
Vickery Tom,
Fisher Elizabeth,
Artino Laura,
Yin Jay,
Hinksmon Joe,
Fine Adam
Publication year - 2018
Publication title -
process safety progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.378
H-Index - 40
eISSN - 1547-5913
pISSN - 1066-8527
DOI - 10.1002/prs.11917
Subject(s) - process safety , anhydrous , thermal stability , process (computing) , chemical safety , hazard , aqueous solution , thermal instability , chemistry , materials science , chemical engineering , work in process , engineering , computer science , organic chemistry , biochemical engineering , operations management , physics , operating system , mechanics
During the process development of a pharmaceutical advanced intermediate, new chemistry using an aqueous workup resulted in the discovery of a new hydrated crystal form of this intermediate. This hydrated crystal form showed thermal instability at a relatively low temperature compared to the original anhydrous form. Thermal stability and associated process safety hazards were investigated in order to ensure process safety and transportation safety of this intermediate. © 2017 American Institute of Chemical Engineers Process Saf Prog 37: 263–267, 2018
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