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ing and Indexing • Embase (Elsevier) • SCOPUS (Elsevier) • MEDLINE/PubMed indexing Society Information The American Society for Clinical Pharmacology and Therapeutics (ASCPT) was founded in 1900, and consists of over 2,200 professionals whose primary interest is to advance the science and practice of clinical pharmacology and translational medicine for the therapeutic benefit of patients and society. ASCPT is the largest scientific and professional organization serving the disciplines of Clinical Pharmacology and Translational Medicine. All articles published in this journal are freely available to read, download, and share. Articles are published under the terms of the Creative Commons Attribution Non-Commercial License which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Disclaimer The Publisher, the American Society for Clinical Pharmacology and Therapeutics, the International Society of Pharmacometrics, and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher, the American Society for Clinical Pharmacology and Therapeutics, the International Society of Pharmacometrics, and Editors, neither does the publication of advertisements constitute any endorsement by the Publisher, the American Society for Clinical Pharmacology and Therapeutics, the International Society of Pharmacometrics, and Editors of the products advertised. Publisher CPT: Pharmacometrics & Systems Pharmacology is published by Wiley Periodicals, Inc., 101 Station Landing, Suite 300, Medford, MA 02155; Telephone: 781388-8200; Fax: 781-388-8210.