Open AccessThe renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
Author(s) -
Braga Cássia L.,
SilvaAguiar Rodrigo P.,
Battaglini Denise,
Peruchetti Diogo B.,
Robba Chiara,
Pelosi Paolo,
Rocco Patricia R. M.,
CarusoNeves Celso,
Silva Pedro L.
Publication year - 2020
Publication title -
pharmacology research and perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.975
H-Index - 27
ISSN - 2052-1707
DOI - 10.1002/prp2.623
Subject(s) - pathogenesis , covid-19 , renin–angiotensin system , disease , medicine , mechanism (biology) , coronavirus , bioinformatics , virology , immunology , biology , infectious disease (medical specialty) , blood pressure , philosophy , epistemology
Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS‐CoV‐2 and SARS‐CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID‐19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID‐19 and potential therapeutic targets, focusing on the role of the renin–angiotensin–aldosterone system.