Open AccessDSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT 1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats
Author(s) -
Kato Taro,
Matsumoto Yuji,
Yamamoto Masanori,
Matsumoto Kenji,
Baba Satoko,
Nakamichi Keiko,
Matsuda Harumi,
Nishimuta Haruka,
Yabuuchi Kazuki
Publication year - 2015
Publication title -
pharmacology research and perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.975
H-Index - 27
ISSN - 2052-1707
DOI - 10.1002/prp2.142
Subject(s) - paroxetine , antidepressant , serotonin transporter , serotonin , serotonergic , serotonin reuptake inhibitor , pharmacology , behavioural despair test , reuptake inhibitor , 5 ht receptor , medicine , serotonin uptake inhibitors , open field , receptor , fluoxetine , hippocampus
Enhancement of serotonergic neurotransmission has been the main stream of treatment for patients with depression. However, delayed therapeutic onset and undesirable side effects are major drawbacks for conventional serotonin reuptake inhibitors. Here, we show that DSP ‐1053, a novel serotonin reuptake inhibitor with 5‐ HT 1A partial agonistic activity, displays fast antidepressant efficacy with minimal undesirable effects, especially nausea and emesis in animal models. DSP ‐1053 bound human serotonin transporter and 5‐ HT 1A receptor with the K i values of 1.02 ± 0.06 and 5.05 ± 1.07 nmol/L, respectively. This compound inhibited the serotonin transporter with an IC 50 value of 2.74 ± 0.41 nmol/L and had an intrinsic activity for 5‐ HT 1A receptors of 70.0 ± 6.3%. In rat microdialysis, DSP ‐1053, given once at 3 and 10 mg kg −1 , dose‐dependently increased extracellular 5‐ HT levels. In the rat forced swimming test, 2‐week administration of DSR ‐1053 (1 mg kg −1 ) significantly reduced rats immobility time after treatment, whereas paroxetine (3 and 10 mg kg −1 ) required 3‐week administration to reduce rats immobility time. In olfactory bulbectomy model, 1‐ and 2‐week administration of DSP ‐1053 reduced both of emotional scores and activity in the open field, whereas paroxetine required 2 weeks to show similar beneficial effects. Although single administration of DSP ‐1053‐induced emesis and vomiting in the rat and Suncus murinus , multiple treatment with this compound, but not with paroxetine, decreased the number of vomiting episodes. These results highlight the important role of 5‐ HT 1A receptors in both the efficacy and tolerability of DSP ‐1053 as a new therapeutic option for the treatment of depression.