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Why do protein architectures have boltzmann‐like statistics?
Author(s) -
Finkelstein Alexei V.,
Badretdinov Azat Ya.,
Gutin Alexander M.
Publication year - 1995
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340230204
Subject(s) - globular protein , globular cluster , statistical physics , amino acid residue , energy (signal processing) , boltzmann constant , biological system , chemistry , biophysics , physics , crystallography , statistics , peptide sequence , mathematics , biology , biochemistry , thermodynamics , quantum mechanics , galaxy , gene
A theoretical study has shown that the occurrence of various structural elements in stable folds of random copolymers is exponentially dependent on the own energy of the element. A similar occurrence‐on‐energy dependence is observed in globular proteins 1 from the level of amino acid conformations to the level of overall architectures. Thus, the structural features stabilized by many random sequences are typical of globular proteins while the features rarely observed in proteins are those which are stabilized by only a minor part of the random sequences. © 1995 Wiley‐Liss, Inc.