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A computer model of the interleukin‐4/receptor complex
Author(s) -
Bamborough Paul,
Grant Guy H.,
Hedgecock Charles J. R.,
West Susan P.,
Richards W. Graham
Publication year - 1993
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340170105
Subject(s) - interleukin 4 receptor , homology modeling , interleukin 4 , homology (biology) , receptor , interleukin 15 , interleukin , folding (dsp implementation) , computational biology , immune system , biology , cytokine , topology (electrical circuits) , chemistry , genetics , biochemistry , amino acid , mathematics , combinatorics , enzyme , electrical engineering , engineering
Interleukin‐4 is a member of the cytokine family, a group of related messenger proteins which collectively help to moderate and control the immune response. It is believed that the folding topology of the β‐sheets of the interleukin‐4 receptor (IL4R) is the same as that seen in the crystal structure of CD4. Although the sequence identity is low, homology modeling techniques have been used to model the IL4R structure from CD4. Refinement by molecular dynamics leads to a suggested structure which has been docked to interleukin‐4 (IL4). Several residues of apparent importance for binding are identified. © 1993 Wiley‐Liss, Inc.