Structural studies of the retroviral proteinase from avian myeloblastosis associated virus | Zendy

Ohiendorf Douglas H. | Zendy; Foundling Steven I. | Zendy; Wendoloski John J. | Zendy; Sedlacek Juraj | Zendy; Strop Peter | Zendy; Salemme F. Raymond | Zendy

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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

Author(s) -

Ohiendorf Douglas H.,

Foundling Steven I.,

Wendoloski John J.,

Sedlacek Juraj,

Strop Peter,

Salemme F. Raymond

Publication year - 1992

Publication title -

proteins: structure, function, and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.699

H-Index - 191

eISSN - 1097-0134

pISSN - 0887-3585

DOI - 10.1002/prot.340140307

Subject(s) - rous sarcoma virus , virology , biology , virus

The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 Å resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase‐inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases. © 1992 Wiley‐Liss, Inc.

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