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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
Author(s) -
Ohiendorf Douglas H.,
Foundling Steven I.,
Wendoloski John J.,
Sedlacek Juraj,
Strop Peter,
Salemme F. Raymond
Publication year - 1992
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340140307
Subject(s) - rous sarcoma virus , virology , biology , virus
The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 Å resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase‐inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases. © 1992 Wiley‐Liss, Inc.