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Hydrogen bonds involving sulfur atoms in proteins
Author(s) -
Gregoret Lydia M.,
Rader Stephen D.,
Fletterick Robert J.,
Cohen Fred E.
Publication year - 1991
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340090204
Subject(s) - hydrogen bond , sulfur , globular protein , crystallography , chemistry , hydrogen , low barrier hydrogen bond , nitrogen , chemical physics , materials science , molecule , organic chemistry
Abstract Intrachain hydrogen bonds are a hallmark of globular proteins. Traditionally, these involve oxygen and nitrogen atoms. The electronic structure of sulfur is compatible with hydrogen bond formation as well. We surveyed a set of 85 high‐resolution protein structures in order to evaluate the prevalence and geometry of sulfur‐containing hydrogen bonds. This information should be of interest to experimentalists and theoreticians intersted in protein structure and protein engineering.