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Acid helix‐turn activator motif
Author(s) -
Zhu QingLin,
Smith Temple F.,
Lathrop Richard H.,
Figge James
Publication year - 1990
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340080205
Subject(s) - transcription (linguistics) , motif (music) , transcription factor , sequence motif , helix turn helix , activator (genetics) , dna , nuclear receptor , computational biology , biology , dna binding protein , receptor , chemistry , microbiology and biotechnology , gene , genetics , physics , philosophy , linguistics , acoustics
A common sequence/structural motif pattern has been identified within the steroid/thyroid hormone receptors and other transcriptional activators using a new massively parallel symbolic learning assistant computer system. The pattern appears nearly diagnostic of transcription activation, including relative activation strength, among nuclear and DNA‐binding prokaryotic proteins. In cases where mutation/deletion/chimeric studies have identified the activation domain, the pattern matches within that domain. These facts and the nature of the pattern itself strongly support the idea that the patterned domain is directly involved in a protein‐protein transcription activation interaction.