A protein structural motif that bends DNA | Zendy

White Stephen W. | Zendy; Appelt Krzysztof | Zendy; Wilson Keith S. | Zendy; Tanaka Isao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A protein structural motif that bends DNA

Author(s) -

White Stephen W.,

Appelt Krzysztof,

Wilson Keith S.,

Tanaka Isao

Publication year - 1989

Publication title -

proteins: structure, function, and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.699

H-Index - 191

eISSN - 1097-0134

pISSN - 0887-3585

DOI - 10.1002/prot.340050405

Subject(s) - dna , bacteriophage , escherichia coli , dna binding protein , biology , computational biology , transcription factor , amino acid , structural motif , chemistry , gene , genetics , microbiology and biotechnology , biochemistry

The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high‐resolution structure of HU, we propose a model for thisinteraction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research