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Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase
Author(s) -
Burke J.,
Hwang P.,
Anderson L.,
Lebo R.,
Gorin F.,
Fletterick R.
Publication year - 1987
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340020303
Subject(s) - glycogen phosphorylase , exon , intron , isozyme , gene , glycogen , glycogen debranching enzyme , phosphorylase kinase , genetics , biology , biochemistry , enzyme
The intron/exon organization of the human gene for glycogen phosphorylase has been determined. The segments of the polypeptide chain that corresponds to the 19 exons of the gene are examined for relationships between the three‐dimensional structure to the protein and gene structure. Only weak correlations are observed between domains of phosphorylase and exons. The nucleotide binding domains that are found in phosphorylase and other glycolytic enzymes are examined for relationships between exons of the genes and structures of the domains. When mapped to the three‐dimensional structures, the intron/exon boundaries are shown to be widely distributed in this family of protein domains.