Premium
Continuous compact protein domains
Author(s) -
Zehfus Micheal H.
Publication year - 1987
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.340020204
Subject(s) - compact space , folding (dsp implementation) , ribonuclease , chemistry , biological system , mathematics , crystallography , physics , biology , pure mathematics , biochemistry , engineering , electrical engineering , rna , gene
The coefficient of compactness was recently introduced and used to locate domains in lysozyme and ribonuclease (Zehfus and Rose: Bio ‐ chemistry 25:5759–5765, 1986). Nineteen additional proteins now have been analyzed by using this measure. Complete listings of compact units and plots showing their hierarchic organization are presented for all twenty‐one proteins. Large compact units correspond well to protein domains; however, many smaller compact structures of equal or better compactness are also found. Since small compact units could represent subdomains or protein‐folding intermediates, their structural composition is further examined.