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The solution structure of the forkhead box‐ O DNA binding domain of B rugia malayi DAF ‐16a
Author(s) -
Casper Sarah K.,
Schoeller Scott J.,
Zgoba Danielle M.,
Phillips Andrew J.,
Morien Thomas J.,
Chaffee Gary R.,
Sackett Peter C.,
Peterson Francis C.,
Crossgrove Kirsten,
Veldkamp Christopher T.
Publication year - 2014
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.24701
Subject(s) - brugia malayi , caenorhabditis elegans , microbiology and biotechnology , biology , chemistry , biochemistry , gene , immunology , filariasis , helminths
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF‐16a, a putative ortholog of Caenorhabditis elegans DAF‐16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF‐16 is involved in the insulin/IGF‐I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF‐16a is a member of the FOXO family of forkhead proteins. Proteins 2014; 82:3490–3496. © 2014 Wiley Periodicals, Inc.