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Crystal structure of a putative quorum sensing‐regulated protein (PA3611) from the Pseudomonas‐specific DUF4146 family
Author(s) -
Das Debanu,
Chiu HsiuJu,
Farr Carol L.,
Grant Joanna C.,
Jaroszewski Lukasz,
Knuth Mark W.,
Miller Mitchell D.,
Tien Henry J.,
Elsliger MarcAndré,
Deacon Ashley M.,
Godzik Adam,
Lesley Scott A.,
Wilson Ian A.
Publication year - 2014
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.24455
Subject(s) - pseudomonas aeruginosa , quorum sensing , protein family , biology , opportunistic pathogen , gene , pathogen , pseudomonas , immune system , microbiology and biotechnology , function (biology) , human pathogen , genetics , computational biology , bacteria , virulence
Pseudomonas aeruginosa is an opportunistic pathogen commonly found in humans and other organisms and is an important cause of infection especially in patients with compromised immune defense mechanisms. The PA3611 gene of P. aeruginosa PAO1 encodes a secreted protein of unknown function, which has been recently classified into a small Pseudomonas‐specific protein family called DUF4146. As part of our effort to extend structural coverage of novel protein space and provide a structure‐based functional insight into new protein families, we report the crystal structure of PA3611, the first structural representative of the DUF4146 protein family. Proteins 2014; 82:1086–1092. © 2013 Wiley Periodicals, Inc.