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The targets of CAPRI rounds 6–12
Author(s) -
Janin Joël
Publication year - 2007
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.21689
Subject(s) - docking (animal) , computational biology , protein structure , macromolecular docking , chemistry , computer science , biology , biochemistry , medicine , nursing
Six protein–protein complexes and two homodimeric proteins involved in a variety of biological processes were offered as targets to CAPRI by crystallographers in Rounds 6–12. CAPRI predictor groups had to predict their structure by docking the free proteins, which they did with a degree of success that depended largely on the amplitude of the conformation changes. In one case at least, the prediction pointed to alternative possibilities of interactions in the crystal of a complex, showing that docking methods have value even when there is an experimental structure. Proteins 2007. © 2007 Wiley‐Liss, Inc.