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Assessment of CASP7 predictions in the high accuracy template‐based modeling category
Author(s) -
Read Randy J.,
Chavali Gayatri
Publication year - 2007
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.21662
Subject(s) - template , computer science , sequence (biology) , quality (philosophy) , protein structure prediction , biological system , artificial intelligence , algorithm , protein structure , chemistry , physics , programming language , biology , biochemistry , quantum mechanics
Models for target domains in the high accuracy template‐based modeling category were assessed according to a number of criteria evaluating the quality of the main‐chain prediction (GDT‐HA), predicted sequence alignment (AL0), and side‐chain rotameric state. A new criterion was introduced, the quality of the model for use in solving a crystal structure by molecular replacement. There is good evidence that modeling adds value to the template structures, particularly when multiple templates are available. However, when there is already a good template, few of the models are better for the purpose of molecular replacement. Proteins 2007. © 2007 Wiley‐Liss, Inc.