Structure of  Xanthomonas axonopodis  pv. citri YaeQ reveals a new compact protein fold built around a variation of the PD‐(D/E)XK nuclease motif | Zendy

Guzzo Cristiane R. | Zendy; Nagem Ronaldo A. P. | Zendy; Barbosa João A. R. G. | Zendy; Farah Chuck S. | Zendy

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Structure of Xanthomonas axonopodis pv. citri YaeQ reveals a new compact protein fold built around a variation of the PD‐(D/E)XK nuclease motif

Author(s) -

Guzzo Cristiane R.,

Nagem Ronaldo A. P.,

Barbosa João A. R. G.,

Farah Chuck S.

Publication year - 2007

Publication title -

proteins: structure, function, and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.699

H-Index - 191

eISSN - 1097-0134

pISSN - 0887-3585

DOI - 10.1002/prot.21556

Subject(s) - nuclease , motif (music) , biology , fold (higher order function) , genetics , microbiology and biotechnology , dna , physics , computer science , acoustics , programming language

The YaeQ family of proteins are found in many Gram‐negative and a few Gram‐positive bacteria. We have determined the first structure of a member of the YaeQ family by X‐ray crystallography. Comparisons with other structures indicate that YaeQ represents a new compact protein fold built around a variation of the PD‐(D/E)XK nuclease motif found in type II endonucleases and enzymes involved in DNA replication, repair, and recombination. We show that catalytically important residues in the PD‐(D/E)XK nuclease superfamily are spatially conserved in YaeQ and other highly conserved YaeQ residues may be poised to interact with nucleic acid structures. Proteins 2007. © 2007 Wiley‐Liss, Inc.

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