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Intrinsic disorder in yeast transcriptional regulatory network
Author(s) -
Singh Gajinder Pal,
Dash Debasis
Publication year - 2007
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.21497
Subject(s) - transcriptional regulation , transcription factor , intrinsically disordered proteins , protein–protein interaction , computational biology , biology , transcription (linguistics) , yeast , genetics , gene , biophysics , linguistics , philosophy
Intrinsic disorder has been shown to be important in mediating protein–protein and protein–DNA interactions. Proteins involved in regulatory functions are particularly enriched in intrinsic disorder. In this study we explored the role of intrinsic disorder in transcriptional regulatory network of yeast. Using disorder prediction programs we show that transcription factors (TFs) regulating large number of targets (transcriptional hubs) have significantly increased intrinsic disorder, though targets regulated by multiple TFs did not show increased intrinsic disorder. Intrinsic disorder may allow these transcriptional hubs to bind to diverse promoter regions of their targets in different contexts, and may also allow complex regulatory control of transcriptional hubs that are involved in coordinating different cellular processes. Proteins 2007. © 2007 Wiley‐Liss, Inc.