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Principles of nanostructure design with protein building blocks
Author(s) -
Tsai ChungJung,
Zheng Jie,
Zanuy David,
Haspel Nurit,
Wolfson Haim,
Alemán Carlos,
Nussinov Ruth
Publication year - 2007
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.21413
Subject(s) - nanostructure , nanotechnology , synthetic biology , computer science , protein design , chemical space , materials science , protein structure , chemistry , computational biology , biology , biochemistry , drug discovery
Currently there is increasing interest in nanostructures and their design. Nanostructure design involves the ability to predictably manipulate the properties of the self‐assembly of autonomous units. Autonomous units have preferred conformational states. The units can be synthetic material science‐based or derived from functional biological macromolecules. Autonomous biological building blocks with available structures provide an extremely rich and useful resource for design. For proteins, the structural databases contain large libraries of protein molecules and their building blocks with a range of shapes, surfaces, and chemical properties. The introduction of engineered synthetic residues or short peptides into these can expand the available chemical space and enhance the desired properties. Here we focus on the principles of nanostructure design with protein building blocks. Proteins 2007. © 2007 Wiley‐Liss, Inc.