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Proteins of the same fold and unrelated sequences have similar amino acid composition
Author(s) -
Ofran Yanay,
Margalit Hanah
Publication year - 2006
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.20964
Subject(s) - amino acid , composition (language) , structural similarity , biochemistry , peptide sequence , protein secondary structure , biology , intramolecular force , sequence (biology) , chemistry , stereochemistry , gene , philosophy , linguistics
It is well established that there is a relationship between the amino acid composition of a protein and its structural class (i.e., α, β, α + β, or α/β). Several studies have even shown the power of amino acid composition in predicting the secondary structure class of a protein. Herein, we show that significant similarity in amino acid composition exists not only between proteins of the same class, but even between proteins of the same fold. To test conjectural explanations for this phenomenon, we analyzed a set of structurally similar proteins that are dissimilar in sequence. Based on this analysis, we suggest that specific residues that are involved in intramolecular interactions may account for this surprising relationship between composition and structure. Proteins 2006. © 2006 Wiley‐Liss, Inc.