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Free modeling with Rosetta in CASP6
Author(s) -
Bradley Philip,
Malmström Lars,
Qian Bin,
Schonbrun Jack,
Chivian Dylan,
Kim David E.,
Meiler Jens,
Misura Kira M.S.,
Baker David
Publication year - 2005
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.20729
Subject(s) - casp , protein structure prediction , computer science , protein structure , computational biology , chemistry , biology , biochemistry
We describe Rosetta predictions in the Sixth Community‐Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP), focusing on the free modeling category. Methods developed since CASP5 are described, and their application to selected targets is discussed. Highlights include improved performance on larger proteins (100–200 residues) and the prediction of a 70‐residue alpha–beta protein to near‐atomic resolution. Proteins 2005;Suppl 7:128–134. © 2005 Wiley‐Liss, Inc.