Predicting novel protein folds by using FRAGFOLD | Zendy

Jones David T. | Zendy

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Predicting novel protein folds by using FRAGFOLD

Author(s) -

Jones David T.

Publication year - 2001

Publication title -

proteins: structure, function, and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.699

H-Index - 191

eISSN - 1097-0134

pISSN - 0887-3585

DOI - 10.1002/prot.1171

Subject(s) - protein structure prediction , protein tertiary structure , simulated annealing , computer science , protein structure , homology (biology) , biological system , homology modeling , algorithm , artificial intelligence , computational biology , pattern recognition (psychology) , biology , genetics , biochemistry , enzyme , gene

The results of applying a fragment‐based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach. Proteins 2001;Suppl 5:127–132. © 2002 Wiley‐Liss, Inc.

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