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Predicting novel protein folds by using FRAGFOLD
Author(s) -
Jones David T.
Publication year - 2001
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.1171
Subject(s) - protein structure prediction , protein tertiary structure , simulated annealing , computer science , protein structure , homology (biology) , biological system , homology modeling , algorithm , artificial intelligence , computational biology , pattern recognition (psychology) , biology , genetics , biochemistry , enzyme , gene
The results of applying a fragment‐based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach. Proteins 2001;Suppl 5:127–132. © 2002 Wiley‐Liss, Inc.