Analysis of the products of genes encompassed by the theoretically predicted pathogenicity islands of  Mycobacterium tuberculosis  and  Mycobacterium bovis | Zendy

Zubrzycki Igor Z. | Zendy

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Analysis of the products of genes encompassed by the theoretically predicted pathogenicity islands of Mycobacterium tuberculosis and Mycobacterium bovis

Author(s) -

Zubrzycki Igor Z.

Publication year - 2003

Publication title -

proteins: structure, function, and bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.699

H-Index - 191

eISSN - 1097-0134

pISSN - 0887-3585

DOI - 10.1002/prot.10586

Subject(s) - mycobacterium bovis , mycobacterium tuberculosis , biology , tuberculosis , genome , gene , pathogenicity , pathogenicity island , genetics , mycobacterium tuberculosis complex , mycobacterium , microbiology and biotechnology , bacteria , medicine , pathology

Sequencing of the genomes of Mycobacterium tuberculosis and Mycobacterium bovis provides a unique opportunity to study the biology of these pathogens on the genomic level. The computational detection of anomalous gene clusters such as those encompassed by pathogenicity islands allows for a narrowing of the study into well‐defined groups of genes. Pathogenicity islands of M. tuberculosis (strains H37Rv and CDC1551) as well as M. bovis genomes comprise a group of genes encoding proteins that have been shown to be of immunological importance. The cross‐genomic comparison ( M. tuberculosis vs M. bovis ) resulted in the elucidation of unique proteins in M. tuberculosis . These proteins may play a significant role in the host recognition process. Proteins 2004; 54:000–000. © 2003 Wiley‐Liss, Inc.

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