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Relationship between protein structures and disulfide‐bonding patterns
Author(s) -
Chuang ChaoChun,
Chen ChunYin,
Yang JinnMoon,
Lyu PingChiang,
Hwang JennKang
Publication year - 2003
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.10492
Subject(s) - disulfide bond , structural similarity , sequence (biology) , similarity (geometry) , protein disulfide isomerase , chemistry , protein structure prediction , hierarchical clustering , cluster analysis , protein structure , crystallography , computational biology , computer science , biochemistry , biology , artificial intelligence , image (mathematics)
We found that that disulfide‐bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide‐bonding patterns and proteins structures. Our findings should be useful in protein structure modeling. Proteins 2003. © 2003 Wiley‐Liss, Inc.