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Consistency matrices: Quantified structure alignments for sets of related proteins
Author(s) -
Van Walle Ivo,
Lasters Ignace,
Wyns Lode
Publication year - 2003
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/prot.10293
Subject(s) - consistency (knowledge bases) , computer science , similarity (geometry) , structural alignment , protein structure database , sequence (biology) , protein structure , structural similarity , pattern recognition (psychology) , data mining , computational biology , artificial intelligence , algorithm , theoretical computer science , sequence alignment , biology , peptide sequence , biochemistry , genetics , sequence database , image (mathematics) , gene
Comparing two remotely similar structures is a difficult problem: more often than not, resulting structure alignments will show ambiguities and a unique answer usually does not even exist. In addition, alignments in general have a limited information content because every aligned residue is considered equally important. To solve these issues to a certain extent, one can take the perspective of a whole group of similar structures and then evaluate common structural features. Here, we describe a consistency approach that, although not actually performing a multiple structure alignment, does produce the information that one would conceivably want from such an experiment: the key structural features of the group, e.g., a fold, which in this case are projected onto either a pair of proteins or a single protein. Both representations are useful for a number of applications, ranging from the detection of (partially) wrong structure alignments to protein structure classification and fold recognition. To demonstrate some of these applications, the procedure was applied to 195 SCOP folds containing a total of 1802 domains sharing very low sequence similarity. Proteins 2003;51:1–9. © 2003 Wiley‐Liss, Inc.