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Orthotopic placement of the dunning R3327 AT‐3 prostate tumor in the copenhagen X fischer rat
Author(s) -
Rubenstein Marvin,
Saffrin Robert,
Shaw Michael,
Muchnik Sergey,
Guinan Patrick
Publication year - 1995
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990270305
Subject(s) - prostate , medicine , prostate disease , prostate cancer , prostate adenocarcinoma , urology , pathology , oncology , cancer
Orthotopic placement of in vitro propagated Dunning R3327 AT‐3 tumor cells resulted in a greater percentage of tumor takes and a two‐fold shift in the exponential growth curve compared to flank implantation. The orthotopic tumor appeared to disseminate preferentially to regional lymph nodes, rather than to the lungs which is characteristic of flank tumors. The results suggest an important role of stromal‐epithelial interactions in the growth of this tumor. © 1995 Wiley‐Liss, Inc.