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Effects of estrogens and progestogens on the membrane permeability and growth of human prostatic carcinoma cells (PC‐3) in vitro
Author(s) -
Widmark Anders,
Henriksson Roger,
Bergh Anders,
Grankvist Kjell,
Damber JanErik
Publication year - 1995
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990260103
Subject(s) - endocrinology , medicine , medroxyprogesterone acetate , estrogen , medroxyprogesterone , androgen , chemistry , in vitro , membrane permeability , hormone , membrane , biochemistry
The effects of estrogens and progestogens in the management of prostatic adenocarcinoma are generally believed to be related to their suppressive effect on the hypothalamic‐pituitary‐testicular axis, but other mechanisms have also been suggested. The present study was designed to investigate if an androgen‐insensitive human prostatic cancer cell line (PC‐3) is sensitive to estrogens or progestogens and to elucidate possible mechanisms of action. Both estrogens and progestogens in high doses (10 −5 M) suppressed tumor cell growth. At these high doses medroxyprogesterone acetate (MPA) most effectively reduced the uptake of 86 rubidium chloride, indicating the strongest effect on ion transport and membrane permeability. Effects on rubidium transport were also seen after estrogen treatment. It is suggested that estrogens and progestogens have direct cytotoxic effects on prostatic carcinoma cells in vitro, possibly by an effect on the cell membrane.