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Ultrasonic diagnosis of 3,2′‐dimethyl‐4‐aminobiphenyl induced tumors in the urogenital organs of F344 rats
Author(s) -
Suzuki Takanori,
Tamura Yoshimi,
Takezawa Yutaka,
Mashimo Tooru,
Imai Kyoichi,
Yuasa Hisako,
Yamanaka Hidetoshi,
Shirai Tomoyuki
Publication year - 1993
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990220306
Subject(s) - genitourinary system , medicine , prostate , pathology , ultrasound , testosterone propionate , lesion , kidney , seminal vesicle , radiology , urology , anatomy , cancer , androgen , hormone
The usefulness of transabdominal ultrasonography in the diagnosis of 3,2′‐dimethyl‐4‐aminobiphenyl‐ and testosterone propionate‐induced tumors of the urogenital organs was evaluated in F344 rats. Seven mass lesions (1 ventral prostate, 1 dorsolateral prostate, 3 seminal vesicles, and 1 kidney) in the urogenital organs could easily be diagnosed concerning size and localization by ultrasound. Histological examination revealed a lesion in the ventral prostate to be an abscess and the other tumors to be malignant. Three hydronephroses by tumor invasion to the ureter, and six tumors in organs other than the urogenital organs could be detected by ultrasound. The threshold of malignant tumor detection by ultrasound was 7 mm in actual length. The size of the mass lesion estimated by ultrasound correlated well with the direct measurement (r = 0.96). Transabdominal ultrasonography is useful for diagnosing the localization of experimental tumors and accurately measuring their size in the urogenital organs of rats. © 1993 Wiley‐Liss, Inc.