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Effect of glycine on retroperitoneal and intraperitoneal organs in the rat model
Author(s) -
Maatman Thomas J.,
Musselman Paul,
Kwak Y. S.,
Resnick Martin I.
Publication year - 1991
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990190406
Subject(s) - medicine , peritoneum , glycine , intraperitoneal injection , pathology , rat model , animal model , retroperitoneal space , anatomy , urology , biology , surgery , biochemistry , amino acid
Twenty Sprague Dawley rats were administered various doses of 1.5% amino acetic acid (glycine), lactated Ringer's, and water, both intravenously and retroperitoneally, in an attempt to recreate the post‐transurethral resection syndrome in a rat model. The kidneys, liver, and pancreas were harvested 6 hours after exposure and examined pathologically. Water and lactated Ringer's had no histologic effect on these organs. Glycine was found to have a toxic effect on the kidneys and liver and this effect was dose related. Based on these results, it is postulated that glycine toxicity may play a significant role as a causative factor in producing the post‐transurethral resection syndrome.