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Immunohistochemical study of metallothionein in normal and benign prostatic hyperplasia of human prostate
Author(s) -
Suzuki Takanori,
Umeyama Tomokazu,
Ohma Chikako,
Yamanaka Hidetoshi,
Suzuki Keiji,
Nakajima Katsuyuki,
Kimura Masami
Publication year - 1991
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990190104
Subject(s) - cystoprostatectomy , prostate , immunohistochemistry , hyperplasia , pathology , metallothionein , stroma , adenoma , urinary bladder , medicine , chemistry , cancer , prostatectomy , cadmium , organic chemistry
Metallothionein (MT) in the human prostate gland was examined. Prostatic tissues were obtained from patients of urinary bladder cancer who had received radical cystoprostatectomy. MT content was 99.3 μg/g wet tissue (w.t.) in the peripheral zone (PZ), 12.0 μg/g w.t. in the preprostatic region (PR), 7.3 μg/g w.t. in the central zone (CZ), 6.8 μg/g w.t. in the anterior fibromuscular stroma, and 29.5 μg/g w.t. in benign nodular hyperplasia (adenoma) by radioimmunoassay. Immunohistochemical study demonstrated that MT was localized in the cytoplasm, nuclei of glandular epithelia, and secretory products. In general, a positive immunoreaction was strong in PZ and weak in CZ. It is considered that glandular epithelial cells in PZ, PR, CZ, and adenoma may react differently to heavy metals, e.g., zinc and cadmium.