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Experimental prostatitis in nonhuman primates: I. Bacterial adherence in the urethra
Author(s) -
Dilworth J. Patrick,
Neal Durwood E.,
Fussell Everett N.,
Roberts James A.
Publication year - 1990
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990170306
Subject(s) - fimbria , prostatitis , urethra , escherichia coli , urology , biology , pathology , medicine , prostate , biochemistry , cancer , gene
Both man and monkey possess urothelial (transitional cell) receptors for P‐fimbriae of Escherichia coli ; however, the male urethra has pseudostratified columnar cells. We studied adherence using scanning electron microscopy and found that P‐fimbriae were the principal mediators of adherence to these cells as well. The monkey, therefore, should be a good model for the study of the ascending route of infection in prostatitis, the route thought to occur in man.