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Effects of epidermal growth factor and androgen influences on accessory sex glands in prepubertal swiss‐webster mice
Author(s) -
Lehman Brenda L.,
Smith Roger,
Leichty Kerry D.,
Kauffman Clint L.,
Miller Roman J.
Publication year - 1990
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990160403
Subject(s) - endocrinology , epidermal growth factor , dihydrotestosterone , medicine , seminal vesicle , androgen , polyamine , prostate , biology , stimulation , epithelium , lumen (anatomy) , hormone , receptor , cancer , genetics
The effects of epidermal growth factor (EGF) on androgen stimulation of accessory sex gland growth and biochemistry were determined for prepubertal male Swiss‐Webster mice. For the seminal vesicle and anterior prostate, 5αdihydrotestosterone (5αDHT) treatment significantly increased the quantitative levels of organ wet weight, DNA content, polyamine content, and stereologically determined epithelium and lumen volumes above the control group. EGF treatment alone slightly enhanced the levels of most measured parameters from control values. However, when a combined EGF5αDHT treatment was compared with 5αDHT treatment alone, the 5αDHT treatment effects on epithelial and lumen volumes and polyamine content were antagonized by the action of EGF.