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Immunohistochemical localization of progesterone receptor in benign and malignant human prostate
Author(s) -
Mobbs B. G.,
Liu Y.
Publication year - 1990
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990160308
Subject(s) - immunohistochemistry , prostate , progesterone receptor , medicine , pathology , receptor , prostate cancer , cancer , estrogen receptor , breast cancer
A monoclonal antibody to progesterone receptor, KD68, was used to localize this receptor protein in 31 surgical specimens of benign and malignant human prostate. Progesterone receptor was detected almost exclusively in stromal cells. The most striking finding was the periacinar arrangement of stained cells in some specimens of glandular BPH, sometimes associated with close apposition of stained cells to the basement membrane of the acinar epithelium. In both benign and malignant specimens scattered stained cells were observed in some areas of fibromuscular stroma. Except for occasional stained epithelial cells in one benign and one estrogen-treated malignant specimen, both benign and malignant epithelium were negative.