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Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging fischer 344 rats
Author(s) -
Wilson Michael J.,
Ditmanson Janet V.,
Sinha Akhouri A.,
Estensen Richard D.
Publication year - 1990
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990160206
Subject(s) - plasminogen activator , endocrinology , prostate , hyperplasia , medicine , activator (genetics) , atrophy , dysplasia , prostate cancer , biology , cancer , receptor
Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30‐month‐old animals demonstrated widespread epithelial atrophy, some foci of inflammation, in‐traglandular atypical hyperplasia and/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low‐ and high‐molecular‐weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue‐type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe‐specific changes in activator activity appear related to dysplasia/neoplasia and not aging.