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Prevention and treatment of experimental prostate cancer in lobund‐wistar rats. I. Effects of estradiol, dihydrotestosterone, and castration
Author(s) -
Pollard Morris,
Luckert Phyllis H.,
Snyder David
Publication year - 1989
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990150203
Subject(s) - castration , dihydrotestosterone , testosterone propionate , medicine , endocrinology , prostate cancer , testosterone (patch) , prostate , androgen , cancer , hormone
The Lobund‐Wistar (L‐W) rat is unique in its susceptibility to spontaneous and induced metastasizing prostate adenocarcinomas (PAS). A single IV inoculation of methylnitrosourea (MNU) produced PAS in 20% of L‐W rats in 12 months. The combination of MNU plus two to seven slow‐release implants of testosterone propionate (TP) induced PAs in 50‐90% of rats respectively in an average of 11.5 months. The induction of PAs was prevented by early treatments of rats at risk with estradiol and less so with dihydrotestosterone (DHT). However, on a technical basis, the results were not significant. Treatments of MNU‐inoculated rats with estradiol, with DHT, or by castration, at intermediate points in the projected latency time of tumor development, reduced significantly the incidences of PA development. Rats in which overt PAS had already developed in response to 12 months of exposure to implants of TP did not respond to treatment by estradiol, DHT, or castration. Thus there are early stage(s) in induced prostate tumorigenesis in L‐W rats that are sensitive to modulating agents.