Premium
Estrogen therapy and liver function—metabolic effects of oral and parenteral administration
Author(s) -
von Schoultz Bo,
Carlström Kjell,
Collste Lars,
Eriksson Ambjörn,
Henriksson Peter,
Pousette Åke,
Stege Reinhard
Publication year - 1989
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990140410
Subject(s) - medicine , estrogen , oral administration , endocrinology , liver function , route of administration
Oral estrogen therapy for prostatic cancer is clinically effective but also accompanied by severe cardiovascular side effects. Hypertension, venous thromboembolism, and other cardiovascular disorders are associated with alterations in liver metabolism. The impact of exogenous estrogens on the liver is dependent on the route of administration and the type and dose of estrogen. Oral administration of synthetic estrogens has profound effects on liver‐derived plasma proteins, coagulation factors, lipoproteins, and triglycerides, whereas parenteral administration of native estradiol has very little influence on these aspects of liver function.