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Monoclonal antibody that defines the prostate specific antigen
Author(s) -
Donn F.,
Bruns T.,
von Meyerinck L.,
Schulz M.,
Becker W.M.,
Becker H.,
Klosterhalfen H.
Publication year - 1989
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990140305
Subject(s) - antigen , monoclonal antibody , immunoperoxidase , prostate specific antigen , antibody , spleen , microbiology and biotechnology , immunohistochemistry , biology , pathology , immunology , prostate , medicine , cancer , genetics
Abstract A monoclonal antibody to a protein with a single band in the 30‐kD region was obtained from fusion of Balb/C mouse spleen cells immunized with epithelial fractions of BPH, with the myeloma cell line P3 × 63 Ag8 6.5.3 by standard procedures. This antigen was characterized in immunobinding studies with various cellular and target antigens and in immunoperoxidase staining.