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Oncogene expression in prostate cancer: Dunning R3327 rat dorsal prostatic adenocarcinoma system
Author(s) -
Cooke D. B.,
Quarmby V. E.,
Mickey D. D.,
Isaacs J. T.,
French F. S.
Publication year - 1988
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990130402
Subject(s) - prostate , prostatic adenocarcinoma , prostate cancer , adenocarcinoma , oncogene , cancer , medicine , prostate adenocarcinoma , dorsum , pathology , biology , cancer research , anatomy , cell cycle
Steady‐state levels of myc, fos, p53, sis, and neu mRNAs were measured in eight variants derived from the Dunning R3327 rat prostate adenocarcinoma and compared to levels in normal dorsal prostate. Expression of the myb and serbB oncogenes in the Dunning tumors was below the limits of detection. Myc, p53, and sis mRNA levels in all tumors were at or above control levels. Fos mRNA levels were below control levels in four of five anaplastic tumors and were above control levels in the remaining tumors. A comparison of mRNA levels along the two Dunning lineages revealed that increased expression of these oncogenes did not correlate with tumor progression.