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Expression of basic fibroblast growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma
Author(s) -
Mydlo Jack H.,
Michaeli Joseph,
Heston W. D. W.,
Fair W. R.
Publication year - 1988
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990130306
Subject(s) - basic fibroblast growth factor , hyperplasia , prostate , prostate cancer , growth factor , fibroblast growth factor , cancer research , carcinoma , messenger rna , medicine , northern blot , endocrinology , cancer , pathology , biology , gene , receptor , biochemistry
In our previous work we demonstrated that prostate‐derived growth factor (PrGF) is homologous to basic fibroblast growth factor (bFGF), not acidic fibroblast growth factor (aFGF). Using Northern blot analysis we now show that the messenger RNA for bFGF but not aFGF is expressed in benign prostatic hyperplastic (BPH) tissue as well as in carcinoma of the prostate (CAP). This not only corroborates our previous results, but suggests that prGF is produced locally and not merely stored in the prostate. The demonstration of local production of bFGF by prostate tissue may indicate that this growth factor plays a role, either alone or in conjunction with other factors, in the etiology of benign hyperplasia or prostatic cancer.