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Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate
Author(s) -
De Voogt H. J.,
Rao B. R.,
Geldof A. A.,
Gooren L. J. G.,
Bouman F. G.
Publication year - 1987
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990110403
Subject(s) - cyproterone acetate , prostate , histology , medicine , androgen , cyproterone , blockade , endocrinology , atrophy , prostate cancer , antiandrogen , feminization (sociology) , hormone , urology , cancer , receptor , social science , sociology
The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl estradiol, prostate volumes again were not changed. However, histology revealed glandular atrophy and an increase in stromal tissue. The significance of these findings is discussed.