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Dihydrotestosterone does not induce prostate adenocarcinoma in L‐W rats
Author(s) -
Pollard Morris,
Snyder David L.,
Luckert Phyllis H.
Publication year - 1987
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990100406
Subject(s) - dihydrotestosterone , testosterone (patch) , prostate , endocrinology , medicine , prostate cancer , androgen , adenocarcinoma , cancer , hormone
Abstract It has been postulated that dihydrotestosterone (DHT) is the active trophic androgen in initiating pathogenic changes in the prostate gland. Groups of prostate cancer‐susceptible male L‐W rats (age 3 months) were treated with subcutaneous depots of testosterone or of DHT. After 14 months, prostate adenocarcinomas had developed in 24% of the testosteronetreated rats but not in the DHT‐treated rats. In the latter rats, the testes were significantly reduced in weight, there was no evidence of spermatogenesis, and serum testosterone levels were not detectable. It appears that DHT as administered to L‐W rats had an antiandrogenic effect.