Premium
Androgen receptors detected by autoradiography in prostatic carcinoma and benign prostatic hyperplastic tissue
Author(s) -
Hulka Barbara S.,
Beckman William C.,
Checkoway Harvey,
Diferdinando George,
Hammond John E.,
Fried Floyd A.,
Mickey Don D.,
Stumpf Walter E.,
Clark Terry D.
Publication year - 1987
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990100305
Subject(s) - hyperplasia , androgen receptor , prostate , medicine , carcinoma , receptor , cancer , pathology , prostatic diseases , androgen , stage (stratigraphy) , prostate cancer , pathogenesis , endocrinology , biology , hormone , paleontology
Androgen receptor (AR) content in prostatic tissues from patients with either cancer or benign prostatic hyperplasia (BPH) is of interest from at least two standpoints: receptors may be a feature of the pathogenesis of these conditions, and they may be important to the management and prognosis of prostatic cancer patients. For these reasons, a quantitative autoradiographic assay for AR content in prostatic tissues has been developed. Application of autoradiography to rodent tissues yielded results that were highly correlated with those from biochemical assays. Thus, the autoradiographic analyses with human tissues reported in this paper were undertaken. Average AR content in 22 prostatic carcinomas was lower than that in tissues from 14 patients with BPH; the median values of the affinity index, the quantitative estimate of receptor content, were 7.0 and 12.0, respectively. For the cancer tissues, a trend of declining receptor content with advancing stage of disease appeared but was not statistically significant. No association between receptor content and degree of tumor aggressiveness as measured by Gleason score and MD Anderson score was evident. Patient age and race were not related to receptor content in either type of tissue.