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Role of epithelial‐stromal interactions in the control of gene expression in the prostate: An hypothesis
Author(s) -
Tenniswood Martin
Publication year - 1986
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990090407
Subject(s) - stromal cell , prostate , stroma , biology , prostate cancer , growth factor , epithelium , cancer research , endocrinology , mechanism (biology) , mechanism of action , medicine , receptor , microbiology and biotechnology , immunohistochemistry , genetics , immunology , in vitro , cancer , philosophy , epistemology
An hypothesis that explains the effects of stromal‐epithelial interactions on the mechanism of action of androgens is presented. This hypothesis proposes the existence of three factors, two growth factors referred to as “stromally derived growth factor” (SDGF) and “epithe‐lially derived growth factor” (EDGF), and one inhibiting factor, “epithelially derived inhibiting factor” (EDIF), which together modulate the replicative and transcriptional processes of the prostate. The hypothesis attempts to explain the well documented modulation of epithelial morphology and function by the stromal cells of the prostate that occurs during development. It also describes the role of each of the factors in the mature prostate, and suggests that in the adult the interaction between the stroma and epithelium, while still significant does not greatly influence the action of androgens, which exert their effects via the classical steroid receptor mechanism.