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Postradiation biopsy and histological effects in early‐stage prostatic cancer treated with 125 iodine implants
Author(s) -
Kandzari Stanley J.,
Riley Roger S.,
Belis John A.,
Jain Pushpa R.
Publication year - 1986
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990090403
Subject(s) - medicine , malignancy , prostate , adenocarcinoma , radiation therapy , biopsy , carcinoma , prostate cancer , stage (stratigraphy) , cancer , urology , surgery , pathology , paleontology , biology
One hundred twenty patients with adenocarcinoma of the prostate were treated with 125 I irradiation to the prostate and pelvic lymphadenectomy. Clinical stages were A‐2 (13 pts), B‐1 (34 pts), B‐2 (49 pts), and C‐1 (24 pts). The tumors were well differentiated in 44%, moderately differentiated in 39% and poorly differentiated in 17%. Nineteen of 22 patients with positive lymph nodes had either moderately or poorly differentiated tumors. A total radiation dosage between 15,000 and 24,000 rads per year were given to all patients. Seventy‐six patients had been rebiopsied at 1 year, and 26 were positive for malignancy (34%). Thirty‐eight patients had rebiopsy at 2 years, and 16 were positive (42%). Forty‐four percent of the postradiation biopsies were of a different histologic grade from the primary lesion. Radiation injury was identified in 95% of the posttreatment biopsies and were moderate or severe in 71%. One hundred one patients are living from 1 to 9 years. Eight patients have died of metastatic carcinoma, and 11 have died of cardiovascular problems.