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Effect of age, castration, and testosterone replacement on the development and restoration of canine benign prostatic hyperplasia
Author(s) -
Berry Stephen J.,
Ewing Larry L.,
Coffey Donald S.,
Strandberg John D.
Publication year - 1986
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990090308
Subject(s) - beagle , castration , medicine , silastic , testosterone (patch) , hyperplasia , prostate , urology , testosterone replacement , androgen , hormone , cancer
An experiment was designed to test the effect of castration and testosterone replacement on the development of benign prostatic hyperplasia (BPH) in young and on the restoration of BPH in old beagles. Twenty beagles were divided by age into young (1.5–2.5–yr) and old (6.0–8.5‐yr) groups. Each of these groups was further divided randomly into two additional groups of age‐matched, intact, untreated control and castrate beagles. The latter were then treated with testosterone‐filled Silastic implants designed to clamp serum testosterone at concentrations similar to those observed in adult beagles for 7 months beginning 5 months after castration. Histopathologic characterization of each prostate was completed on biopsy material obtained at the beginning and end of the experiment. Prostate weights were determined each month for 12 months via a noninvasive two‐dimensional X‐ray procedure [1]. Testosterone treatment for 7 months allowed BPH to develop in young and restored BPH in old beagles. These results suggest that testosterone in the adult beagle acts permissively to allow BPH to develop in the prostrate of the aging dog. Some other testicular product may be required for the continued growth of BPH in aged beagles.