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Biosynthesis of immunoreactive inhibin‐like material (IR‐ILM) by rat prostate
Author(s) -
Sathe V. A.,
Sheth A. R.,
Sheth N. A.
Publication year - 1986
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990080411
Subject(s) - prostate , medicine , biosynthesis , in vitro , endocrinology , testosterone (patch) , estrogen , hormone , chemistry , biochemistry , cancer , enzyme
Presence of biologically active inhibin‐like material (ILM) in the rat prostate was demonstrated by suppression of in vitro follicle‐stimulating hormone release from rat pituitaries, and its in vitro biosynthesis was studied by immunoprecipitation of 3 H‐leucine incorporated in ILM. In vitro biosynthesis of immunoreactive ILM (IR‐ILM) was greater in prostate from castrated as compared to intact rats and it decreased in prostates from castrated rats treated with testosterone. In prostates from estrogen‐treated castrated animals, an increase in IR‐ILM synthesis was observed. These observations indicated that in addition to the testes prostate could be an additional source of ILM and that IR‐ILM synthesis in prostate is modulated by hormones.