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Changes of cytosol proteins in the ventral and dorsolateral prostates of rats during sexual maturation: Immature prostate‐abundant proteins as detected by polyacrylamide gel electrophoreses
Author(s) -
Wada Fumio,
Nishi Nozomu,
Muguruma Yasuyoshi,
Tanaka Yukio,
Matuo Yuhsi
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990070408
Subject(s) - prostate , cytosol , dorsolateral , biology , polyacrylamide gel electrophoresis , secretory protein , endocrinology , molecular mass , medicine , chemistry , andrology , secretion , biochemistry , enzyme , cognition , cancer , neuroscience , prefrontal cortex
Abstract Cytosol proteins in the ventral and dorsolateral prostates of rats from four to 31 weeks of age were analyzed by SDS‐electrophoresis. By comparing the relative contents (% of the total protein), it was found that in addition to the known major proteins which became abundant with age, there were several species abundant in the sexually immature prostates: (1) Ventral prostate: two kinds of secretory proteins with apparent molecular weights of about 31,000 (31K) and 67,000 (67K) and five kinds of nonsecretory proteins (42K, 57K, 58K, 80K and 84K) were abundant at weeks 4‐5; the most susceptible species was 80K, whose content at week 4 decreased to about one tenth at week 31. (2) Dorsolateral prostate: a nonsecretory protein (41K) and 14.4K, 34K, 80K, and 85K, which were distributed into the secretory and nonsecretory fractions, were abundant at weeks 4‐7; the most susceptible species was 80K, whose content at week 4 decreased to about one tenth after week 11. Total contents (content/100 g body weight) of all the protein species increased by aging in either prostate; the most susceptible species were 13K in the ventral prostate and 120K in the dorsolateral prostate, whose total contents increased 90‐100 times during sexual maturation.