Premium
Benign hyperplasia of ventral prostate in rats induced by a monoterpene (preliminary report)
Author(s) -
Abramovici Armand,
Sandbank Uriel,
Servadio Ciro
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990070407
Subject(s) - hyperplasia , citral , prostate , monoterpene , histology , medicine , muscle hypertrophy , pathology , chemistry , food science , essential oil , biochemistry , cancer
This is a preliminary report on the experimental induction of benign prostatic hypertrophy in rats using the nonsteroidal compound, citral, a monoterpene that is widely used in the cosmetics, cleaning, and food industries. The shaved skin of rats 6 weeks of age was smeared daily with citral for 3 months. The ventral prostates of the treated rats were larger and heavier than those of controls, and histology revealed a typical benign process of hyperplasia. Further studies are in progress to assess the nature of the mechanism involved.